Master / graduate projects in Life Sciences (Stage)

We are looking for highly motivated M2 or PhD students starting anytime. The IGBMC is a leading European center for biomedical research and provides superior infrastructures of facilities and platforms. The team of Jocelyn Laporte and Johann Bohm works on congenital myopathies, which are severe muscle disorders strongly impacting on the quality of life of patients. Our international team is composed of about 20 members with different and complementary expertise (www.igbmc.frLaporte) and we address following major points: -The genetic causes of congenital myopathies -The physiopathology underlying these disorders * The development of therapeutic approaches We have access to DNA samples from a large number of patients, and we have validated cell and animal models. We have established a panel of multi-disciplinary state-of-the-art techniques and approaches to investigate normal and pathological muscle cells and tissue, and we are also able to modulate the expression or activity of proteins by pharmacological compounds or the use of viral vectors (AAVs). Identifying the genetic basis of muscle diseases and validating therapeutic proof-of concepts is essential for a better diagnosis, health care and to develop clinical trials. We are looking for a PhD student for 3 years or master/graduate students for a final 6-12 months internship in our team with the perspective to continue with a PhD on any of the mentioned thematic of the team. The team language is English. Location : IGBMC is one of the main European research center in Biomedicine, located in Strasbourg, at the border with Germany and less than 2hrs train from Paris, within a nice and typical countryside near the Vosges mountains. 750 persons from 40 nationalities work at IGBMC which houses a large number of state-of-the-art scientific platforms/services. References : (*PhD student) -Lornage X* et al. ACTN2 mutations cause "Multiple structured Core Disease" (MsCD). Acta Neuropathol. 2019 Mar;137(3):501-519. doi: 10.1007/s00401-019-01963-8 -Lionello VM* et al. Amphiphysin 2 (BIN1) modulation rescues MTM1 centronuclear myopathy and prevents focal adhesion defects. Sci Transl Med. 2019 Mar 20;11(484). doi: 10.1126/scitranslmed.aav1866. Silva-Rojas* et al. STIM1 over-activation generates a multi-systemic phenotype affecting the skeletal muscle, spleen, eye, skin, bones and immune system in mice. Hum Mol Genet. 2019 May 15;28(10):1579-1593. doi: 10.1093/hmg/ddy446. Application : Applications including a motivation letter, CV, previous marks and ranking, and recommendation letters or references should be sent as a single document by email to jocelyn@igbmc.fr and johann@igbmc.fr. Référence MASTER / GRADUATE PROJECTS IN LIFE SCIENCES – STRASBOURG – FRANCE Type de contrat STAGE Date de publication 14/01/2022