Preclinical biomarker lead scientist
Detail de l'annonce :
The senior scientist will be responsible for delivering high quality
data supporting projects and assets across the portfolio in the areas
of: developing/sourcing models to support translational research,
evaluating drug efficacy, deciphering mechanism of action, developing
and validating pharmacodynamic biomarkers, identifying stratification
strategies, driving drug combination evaluations, investigating
differentiation factors. He/she will cover all three therapeutic areas
(oncology, neurology and rare diseases) and will adapt execution to
resource forecast (i.e. internal work or CROs).
He/She will define translational science plans for each relevant
program, covering all aspects listed above and will be accountable for
on-time results delivery.
Main responsibilities / job expectations
Primary responsibilities:
* Identifies key scientific questions in the projects and builds
translation sciences plan according to their priority level.
* Propose relevant methodologies to answer those key questions and
identify and/or develops methods accordingly (internally or at CROs)
* Independently design, implement and conduct preclinical experiments
to investigate mechanism of action of drugs.
* Design and conduct studies to evaluate novel indications, including
stratification strategy, and/or combinations.
* Identify, develop and validate biomarker of target engagement,
efficacy and/or resistance for preclinical use with potential to be
translated to the clinic.
* Work autonomously and provide strong scientific input to advance
translational activities, critically influencing the clinical
development of anti-cancer drugs.
* Perform all data analysis and ensure statistical analysis are run
to guarantee accuracy of the data.
* Provide scientific and/or technical guidance and input to assistant
researcher and junior scientists.
* Actively participate in meetings and effectively interfaces with
technical/scientific experts in all functions.
* Manage outsourcing process according to Ipsen SOPs (budget,
contracts…).
* Communicate effectively and impactfully across the organization
within REED and with Clinical Development, Project Management,
Regulatory, R&D and BD, as well as with external partners.
* Complete performance reviews and development plan for team as
required
* Keep up to date with the scientific literature in the fields of
interest and attend scientific conferences.
* Ensures compliance with appropriate SOP's .
EHS responsibilities:
* Comply with applicable EHS regulations and procedures.
* Participate in the site's EHS performance by reporting risks,
malfunctions or improvements
Participate in mandatory EHS training
Knowledge, abilities & experience
Education / Certifications:
* Minimum requirements/Education (minimum/desirable):
* PhD + Post doc in life science, preferably in oncology or
immuno-oncology; ability to travel up to 5%
* An equivalent combination of relevant education and applicable job
experience may be considered.
Experience:
* 5+ years experience in drug development in the pharmaceutical
industry or in biotech, including 2+ years experience in early phase
clinical biomarker
Languages:
* French: Business level, oral and written
* English: Business level, oral and written
Key Technical Competencies Required
* Highly skilled regarding in vitro and ex vivo pharmacology
activities/technologies
* Capable of developing new techniques and methodologies
* Excellent expertise in cell culture, cellular and molecular
biology, immunology and biochemistry methods
* Good knowledge of flow cytometry and multiparametric analysis
* Deep understanding of the role of translational science and
clinical biomarkers in drug development
* Demonstrated experience in the appropriate application of various
scientific technologies into translational research strategies
* Comfortable working in a fast-paced environment
* Comfortable working in or leading a matrix team
* Ability to recognize, articulate, and accept calculated risks to
make informed decisions
* Working knowledge of all functional areas of drug development,
including pharmacology, toxicology, clinical development, diagnostic
development
* Good analytical and problem-solving skills
* Excellent scientific written, interpersonal communication
* Strong familiarity with good clinical/laboratory practices
* Good experience working with CROs.
* Eager and interested in learning and growing
Other Useful Information
* Key Internal stakeholders: REED members, Asset/Project teams, CDO,
Therapeutic areas, R&D, GRDQA
* Key External contacts: CROs, partners/collaborators
* Financial budget: internal and external
* Number of direct reports: 1-2
The statements contained herein reflect general details as necessary
to describe the principles functions for this job, the level of
knowledge and skill typically required, and the scope of
responsibility, but should not be considered an all-inclusive listing
of work requirements. Individuals may perform other duties as
assigned, including work in other functional areas to cover absences
or relief, to equalize peak work periods or otherwise balance
workload.
This description is not intended to be constructed as an exhaustive
list of duties, responsibilities, or requirements for the position.
This position may change or assume additional duties at any time. The
employee may be requested to perform different or additional duties as
assigned. All Employees are expected to adhere to all company policies
and act as a role model for company values.
Dans le cadre de ses recrutements IPSEN s’engage au respect de
l’égalité de traitement des candidats, indépendamment du sexe, de
l’âge, de l'orientation sexuelle, de l'origine ethnique, de la
couleur de la peau, de la nationalité, du handicap ou de
l'appartenance à un syndicat.