postdoctoral position in medicinal chemistry ibmm montpellier france
Detail de l'annonce :
University of Montpellier, Institut des Biomolécules Max Mousseron,
UMR 5247 CNRS UM ENSCM). Research activities of IBMM lie at the
interface between chemistry and biology aiming to study and gain
insight into the mechanims of action of biomolecules and the treatment
of human and animal pathologies (infectious, cardio-vascular,
degenerative, cancer...) with applications for tomorrow’s molecular
medicine.
SITE WEB :
http://ibmmpeptide.com/
POSTE ET MISSIONS
The post-doctoral research assistant will be in charge of the
development of proteolysis targeted chimera (PROTAC) molecules with
potential applications in DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG).
DIPG is an incurable pediatric cancer characterized by epigenetic
alterations and abnormal activation of several KINASE RECEPTORS. Small
molecule inhibitors targeting these mutations were developed but did
not show sufficient efficacy in DIPG. Thus, the objective of this
project is to develop PROTAC derivatives with enhanced properties
exploiting these targets.
Synthesis of inhibitors, optimization of the LINKER PART of the
PROTACs and study of different RECRUITING ELEMENTS will allow to
constitute several LIBRARIES OF PROTAC. We have partnered with a
biology team interested in the development of innovative therapies in
DIPG in order to test these PROTAC compounds and validate their
efficacy _in vitro_ (alone or in combination). Their ability to cross
the blood-brain barrier and their ability to eliminate DIPG cells _in
vivo_ will also be explored.
MOBILITÉ GÉOGRAPHIQUE :
Pas de déplacement
PRISE DE FONCTION :
16/05/2022
PROFIL
The post-doc fellowship is granted by the French National Institute of
Cancer (INCa) for 12 MONTHS. The contract could be possibly extended.
Candidates should have a PhD and strong skills in Organic Chemistry.
An experience in Medicinal Chemistry is not required but would be
appreciated.