Preclinical biomarker lead scientist

The senior scientist will be responsible for delivering high quality data supporting projects and assets across the portfolio in the areas of: developing/sourcing models to support translational research, evaluating drug efficacy, deciphering mechanism of action, developing and validating pharmacodynamic biomarkers, identifying stratification strategies, driving drug combination evaluations, investigating differentiation factors. He/she will cover all three therapeutic areas (oncology, neurology and rare diseases) and will adapt execution to resource forecast (i.e. internal work or CROs). He/She will define translational science plans for each relevant program, covering all aspects listed above and will be accountable for on-time results delivery. Main responsibilities / job expectations Primary responsibilities: * Identifies key scientific questions in the projects and builds translation sciences plan according to their priority level. * Propose relevant methodologies to answer those key questions and identify and/or develops methods accordingly (internally or at CROs) * Independently design, implement and conduct preclinical experiments to investigate mechanism of action of drugs. * Design and conduct studies to evaluate novel indications, including stratification strategy, and/or combinations. * Identify, develop and validate biomarker of target engagement, efficacy and/or resistance for preclinical use with potential to be translated to the clinic. * Work autonomously and provide strong scientific input to advance translational activities, critically influencing the clinical development of anti-cancer drugs. * Perform all data analysis and ensure statistical analysis are run to guarantee accuracy of the data. * Provide scientific and/or technical guidance and input to assistant researcher and junior scientists. * Actively participate in meetings and effectively interfaces with technical/scientific experts in all functions. * Manage outsourcing process according to Ipsen SOPs (budget, contracts…). * Communicate effectively and impactfully across the organization within REED and with Clinical Development, Project Management, Regulatory, R&D and BD, as well as with external partners. * Complete performance reviews and development plan for team as required * Keep up to date with the scientific literature in the fields of interest and attend scientific conferences. * Ensures compliance with appropriate SOP's . EHS responsibilities: * Comply with applicable EHS regulations and procedures. * Participate in the site's EHS performance by reporting risks, malfunctions or improvements Participate in mandatory EHS training Knowledge, abilities & experience Education / Certifications: * Minimum requirements/Education (minimum/desirable): * PhD + Post doc in life science, preferably in oncology or immuno-oncology; ability to travel up to 5% * An equivalent combination of relevant education and applicable job experience may be considered. Experience: * 5+ years experience in drug development in the pharmaceutical industry or in biotech, including 2+ years experience in early phase clinical biomarker Languages: * French: Business level, oral and written * English: Business level, oral and written Key Technical Competencies Required * Highly skilled regarding in vitro and ex vivo pharmacology activities/technologies * Capable of developing new techniques and methodologies * Excellent expertise in cell culture, cellular and molecular biology, immunology and biochemistry methods * Good knowledge of flow cytometry and multiparametric analysis * Deep understanding of the role of translational science and clinical biomarkers in drug development * Demonstrated experience in the appropriate application of various scientific technologies into translational research strategies * Comfortable working in a fast-paced environment * Comfortable working in or leading a matrix team * Ability to recognize, articulate, and accept calculated risks to make informed decisions * Working knowledge of all functional areas of drug development, including pharmacology, toxicology, clinical development, diagnostic development * Good analytical and problem-solving skills * Excellent scientific written, interpersonal communication * Strong familiarity with good clinical/laboratory practices * Good experience working with CROs. * Eager and interested in learning and growing Other Useful Information * Key Internal stakeholders: REED members, Asset/Project teams, CDO, Therapeutic areas, R&D, GRDQA * Key External contacts: CROs, partners/collaborators * Financial budget: internal and external * Number of direct reports: 1-2 The statements contained herein reflect general details as necessary to describe the principles functions for this job, the level of knowledge and skill typically required, and the scope of responsibility, but should not be considered an all-inclusive listing of work requirements. Individuals may perform other duties as assigned, including work in other functional areas to cover absences or relief, to equalize peak work periods or otherwise balance workload. This description is not intended to be constructed as an exhaustive list of duties, responsibilities, or requirements for the position. This position may change or assume additional duties at any time. The employee may be requested to perform different or additional duties as assigned. All Employees are expected to adhere to all company policies and act as a role model for company values. Dans le cadre de ses recrutements IPSEN s’engage au respect de l’égalité de traitement des candidats, indépendamment du sexe, de l’âge, de l'orientation sexuelle, de l'origine ethnique, de la couleur de la peau, de la nationalité, du handicap ou de l'appartenance à un syndicat.